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Pr proinsuline Formation de l insuline partir de la proinsuline La pr proinsuline est le produit de l expression du g ne INS et compte 110 r sidus d acides amin s L limination des 24 r sidus C terminaux formant le peptide signal au niveau du r ticulum endoplasmique donne la proinsuline laquelle est convertie en insuline par limination de 35 r sidus entre les cha nes A et B

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A novel cereblon modulator recruits GSPT1 to the CRL4CRBN
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